2026-10-282026-10-282026MENDONÇA, Suellen da Silva. Avaliação da relação entre função autonômica cardíaca, inflamação sistêmica e da qualidade de vida na COVID longa: estudo transversal. Orientador: Luiz Fábio Magno Falcão. 2026. 56 f. Dissertação (Programa de Pós Graduação em Reabilitação e Desempenho Funcional) - Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém, 2026.https://portaldaposgraduacao.uepa.br/handle/riuepa/394AbertoCovidQualidade de vidaSistema nervosoCoração - doençaCitocinaCovidquality of lifenervous systemheart - diseasecytokineDissertaçãoCiências BiológicasLong COVID refers to symptoms lasting longer than 2–3 months, affecting various organs and systems such as the respiratory, neurological, and muscular systems as well as cardiovascular manifestations, particularly cardiovascular autonomic dysfunction, which may be related to early-stage inflammation caused by an imbalance between proinflammatory and anti-inflammatory cytokines, thereby affecting functional capacity, and other aspects related to quality of life. Objectives: To assess cardiac autonomic modulation, quality of life, and their relationship with inflammation in individuals with Long COVID. Methodology: A cross-sectional observational study conducted between 2020 and 2025, involving 128 adults with a confirmed diagnosis of Long COVID. The sample was selected by convenience, and data were collected through assessment of HRV, administration of the SF-36 and the Post-COVID-19 Functional Scale, and cytokine analysis, in addition to screening for sociodemographic and clinical data. The study was conducted in accordance with the STROBE guidelines. A p-value of <0.05 was adopted as the threshold for statistical significance. Results: Individuals with greater functional limitations had higher concentrations of IL-17A. The cytokines IL-6, IL-17A, IL-4, and IFN-γ were associated with functionality and the physical domains of quality of life, while changes in the RR, SDNN, RMSSD, and SD1/SD2 indices were primarily related to the mental domains of the SF-36. Correlation analysis revealed associations between inflammatory markers, cardiac autonomic modulation, and quality of life. Conclusion: The findings reinforce the multifactorial nature of Long COVID, demonstrating that persistent systemic inflammation and alterations in autonomic modulation act in a complementary manner to impair functionality and quality of life, with predominant associations with different domains.PPGREAB - Avaliação e intervenção terapêutica nos sistemas neuromuscular