2024-09-092024-09-092023LIMA, Tatiana Fabíola da Silva. Avaliação do potencial clareador do extrato hidroalcoólico da casca de Calycophyllum Spruceanum (Benth.) K. Schum em manchas hiperpigmentadas. 2023. 59 f. Orientador: Seidel Ferreira dos Santos. Dissertação (Mestrado em Tecnologia, Recursos Naturais e Sustentabilidade na Amazônia) - Centro de Ciências Naturais e Tecnologia, Universidade do Estado do Pará, Belém, 2023.https://portaldaposgraduacao.uepa.br/handle/riuepa/176Fundação Amazônia Paraense de Amparo à Pesquisa, FAPESPAAbertoCalycophyllum spruceanumEtnofarmacologiaManchasHipercromiaPelePlantas medicinaisMatéria médica vegetalEtnobotânicaEthnopharmacologySpotsHyperchromiaSkinDissertaçãoCiências da Saúde::Farmácia::FarmacotecniaThe study focuses on Calycophyllum spruceanum (Benth.) K. Schum, known as "pau-mulato," a species belonging to the Rubiaceae family. This family is vast, encompassing thousands of species and genera worldwide, with around 130 genera and 1,500 species just in Brazil, 258 of which are found in the Amazon, including 174 exclusive to the region. Active compounds within this family include iridoids, alkaloids, and anthraquinones. The tree is prevalent in the Amazon region, particularly in floodplain areas, pastures, and areas affected by environmental degradation. Its dispersal occurs along the Amazon River, with seedlings taking root in clayey and flood-prone soils. Scientific literature mentions the plant's medicinal properties, such as anti-inflammatory, antioxidant, and antimicrobial actions, yet there are limited studies on its pharmaceutical aspects. The bark of the stem is widely used in the form of teas or topical infusions to treat inflammations, skin infections, and hyperpigmentation—a common condition caused by excessive melanin production, leading to aesthetic problems. Due to the demand for its products, concerns arise regarding the tree's predatory exploitation. A study conducted at the Federal University of Pará aimed to assess the skin lightening potential of C. spruceanum bark on hyperpigmented spots. Tests were conducted to identify compounds present in the plant, such as condensed and hydrolysable tannins, reducing sugars, and chemical profiling via gas chromatography coupled with mass spectrometry. The results indicated the presence of compounds like fatty acids, terpenic derivatives, and phenolics, suggesting antioxidant and lightening actions. The presence of palmitic acid showed potential as an acylcarnitine inhibitor, acting as an antioxidant and neuroprotective agent. Other compounds like phytol exhibited inhibition of retinol, used in cell renewal, while phenols stood out for their inhibition of tyrosinase, an enzyme pivotal in melanin production. In conclusion, the research suggests that C. spruceanum holds skin-lightening potential for hyperpigmented spots, showcasing a variety of compounds with properties that could influence skin pigmentation regulation.PPGTEC - Gestão de recursos agroflorestais