2026-11-092026-11-092026-01-15GRAÇA, Victor Viana da. Análise epidemiológica e espacial da doença de chagas aguda (DCA) em um município amazônico: uma abordagem de saúde única (one health) do processo saúde-doença. Orientador: Juarez Antônio Simões Quaresma. 2026. 100 f. Tese (Doutorado em Biologia Parasitária na Amazônia) - Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém, 2026.https://portaldaposgraduacao.uepa.br/handle/riuepa/437AbertoDoença de ChagasEpidemiologiaSaúde únicaAmazôniaAnálise espacialChagas diseaseEpidemiologyOne HealthAmazonSpatial analysisTeseCiências da SaúdeCiências da Saúde::Saúde ColetivaCiências da Saúde::Saúde Coletiva::EpidemiologiaCiências da Saúde::Saúde Coletiva::Saúde PublicaCiências BiológicasCiências Biológicas::ParasitologiaCiências Exatas e da Terra::GeoCiênciasAcute Chagas Disease (ACD) remains a significant public health problem in the Amazon region, particularly in the state of Pará, which accounts for the majority of reported cases in Brazil. This doctoral thesis aimed to provide an integrated analysis of the epidemiological, spatial, environmental, entomological, and sociocultural aspects of ACD in an Amazonian municipality, based on the One Health approach, understanding the health–disease process as the result of interactions among humans, vectors, animals, food systems, and the environment. This mixed-methods study comprised an integrative literature review, observational studies using secondary data, and spatial analyses, drawing on information from the Notifiable Diseases Information System (SINAN), entomological surveillance records, and environmental datasets. The integrated findings indicate that ACD exhibits a focal endemic-epidemic pattern, characterized by high incidence in specific territories, pronounced seasonality, and a predominance of oral transmission, strongly associated with the consumption of regionally produced foods, particularly artisanally processed açaí. The disease disproportionately affects young adults of working age, primarily individuals with low educational attainment, living in both urban and rural areas, reflecting underlying socioeconomic and territorial vulnerabilities. Spatial analyses revealed a clear overlap between areas with higher occurrence of human cases, the presence of triatomine vectors in intra- and peridomestic environments, preserved or disturbed sylvatic ecotopes, and artisanal food processing sites, underscoring the complexity of transmission dynamics in the Amazonian context. From an environmental perspective, factors such as deforestation, land-use and land-cover changes, unplanned urban expansion, and ecosystem disturbance contribute to the displacement of vectors and reservoirs into human environments, increasing the risk of transmission. The integration of epidemiological, entomological, and environmental evidence reinforces that ACD cannot be adequately understood through fragmented analyses. Instead, it requires intersectoral strategies that integrate epidemiological, sanitary, entomological, and environmental surveillance with health education and food safety actions. In conclusion, the One Health approach is essential for addressing ACD in the Amazon, as it enables a comprehensive understanding of disease determinants and supports the development of more effective, sustainable, and territorially adapted public health policies.PPG-BPA - Epidemiologia de microrganismos e parasitos