2026-11-092026-11-092026-03FIGUEIRA, Luiza Raquel Tapajós. Perfil clínico-epidemiológico e espacial por grau de incapacidade física da hanseníase no Estado do Pará, Amazônia brasileira (2013 a 2024): um estudo transversal. Orientadora: Lima, Luana Nepomuceno Gondim Costa. 2026. 53 f. Dissertação (Mestrado em Biologia Parasitária na Amazônia) - Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém, 2026.https://portaldaposgraduacao.uepa.br/handle/riuepa/436AbertoHanseníaseEpidemiologiaLeprosyEpidemiologyDissertaçãoCiências BiológicasCiências Biológicas::MicrobiologiaCiências Biológicas::Microbiologia::Biologia e Fisiologia dos MicroorganismosLeprosy is a Neglected Tropical Disease, with high prevalence in countries such as India, Brazil and Indonesia. In Brazil, Pará is a critical region, with high prevalence and active transmission, including among children under 15 years of age, which highlights shortcomings in early detection and in breaking the chain of infection. The aim of the study was to describe the prevalence of the degree of physical disability associated with leprosy at diagnosis and its spatial distribution in the state of Pará between 2013 and 2024. This is a cross-sectional, descriptive and retrospective study, based on secondary data from SINAN. A total of 29,644 cases reported between 2013 and 2024 were included. The variables analysed included age, sex, race/ethnicity, educational attainment, area of residence, clinical form, operational classification and Degree of Physical Disability (GIF). Statistical analysis was performed using Jamovi software, and spatial distribution was analysed using geotechnologies. The results demonstrated a predominance of cases among men (63%), adults aged 26–55 years, people of mixed-race (73%), those with low educational attainment, and residents of urban areas, in the clinical forms: dimorphic (53%) and multibacillary (78%). At diagnosis, 36% had physical disability, with a significant GAF score of II, indicating late diagnosis. Following cure, there was a reduction in cases of disability, but 47% were not assessed, revealing shortcomings in post-treatment surveillance; in small municipalities such as Inhangapi, Oriximiná, Anajás and Abel Figueiredo, there were alarming prevalence rates, constituting critical areas of transmission, with around 10% of cases occurring in children under 15 years of age, confirming active transmission. The evidence suggests that leprosy in Pará is strongly associated with social vulnerability, low educational attainment and weaknesses in primary healthcare. The high proportion of multibacillary cases and GIF II cases reinforces the issue of late diagnosis and the need for more effective public policies. Spatial heterogeneity shows that small municipalities account for a high concentration of both early-stage and advanced cases, making them epicentres of the disease. The study confirms that leprosy in Pará remains an endemic disease with significant social and epidemiological impact, with late diagnosis being one of the main challenges; active transmission among children highlights gaps in surveillance, the uneven distribution of the disease requires specific strategies for vulnerable municipalities, and the lack of post-treatment assessment compromises the prevention of sequelae. It is therefore urgent to strengthen primary care, active case finding, continuous monitoring and rehabilitation programmes, especially in critical and isolated areas.PPG-BPA - Morfofisiologia e genética dos agentes infecciosos, parasitários e vetores de endemias na Amazônia