2026-11-112026-11-112026CARVALHO, Thalissa Fernandes. Alterações bioquímicas e nutricionais em pacientes com doença de Chagas crônica. Orientador: Smayk Barbosa Sousa. 2026. 45 f. Dissertação (Mestrado em Biologia Parasitária na Amazônia) - Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém, 2026.https://portaldaposgraduacao.uepa.br/handle/riuepa/441AbertoDoença de ChagasDoença parasitáriaChagas diseaseTrypanosoma cruziParasitic diseaseDissertaçãoCiências BiológicasCiências Biológicas::ParasitologiaChagas disease constitutes a significant public health problem in Latin America, characterized by cardiac, digestive, and metabolic impairments that impact patients' quality of life. Scientific evidence indicates that biochemical and nutritional alterations play a relevant role in the disease's progression, reflecting both the chronic inflammatory state and the physiological response to infection. Thus, this study aimed to systematically analyze the biochemical and nutritional alterations in patients with chronic Chagas disease, including a quantitative synthesis (meta-analysis) of the main metabolic outcomes and nutritional status. This is a systematic review and meta analysis conducted according to the PRISMA 2020 guidelines. The risk of bias was assessed using the Newcastle-Ottawa scale and the Cochrane Risk of Bias tool. Quantitative synthesis was performed using a random-effects model (REML), employing standardized mean differences (SMD), heterogeneity expressed by I², and publication bias assessment by funnel plot inspection and Egger's test, when applicable. The certainty of the evidence was qualified using the GRADE system. 112 records were identified, of which 5 studies were included for meta-analysis. Variables included glycemia, triglycerides, total cholesterol, serum proteins, and body mass index (BMI). A dual profile was observed among the participants: hospitalized patients presented sarcopenia and elevated AST, ALT, and creatinine, while outpatients exhibited central obesity, systemic inflammation, and increased levels of hs-CRP. The meta-analysis demonstrated a significant combined effect for metabolic alterations (SMD = 0.41; 95% CI 0.21–0.61; I² = 49%). It is concluded that chronic Chagas disease is associated with clinically relevant biochemical and nutritional dysfunctions, modulated by clinical and social factors. Future studies are recommended to address the implementation of integrated strategies for laboratory surveillance, continuous nutritional assessment, and individualized dietary interventions.PPG-BPA - Epidemiologia de microrganismos e parasitos